EPS4.02 Earlier identification of cystic fibrosis diabetes in children with cystic fibrosis – real-world experience on the use of continuous (flash) glucose monitoring

Background: Annual screening for CF diabetes (CFD) is recommended from aged 10 years. A 2 hour blood glucose (BG) reading on OGTT of >11.1 mmol/l diagnostic CFD, however data incidence impaired tolerance (IGT) are limited. Continuous monitoring (CGM) alongside regular diet better defines daily BG excursions aiding interpretation glycaemic control. UK guidelines recommend both & CGM as suitable methods CFD - our centre’s present pathway to undertake in all with an abnormal result. Objective: Review single-centre experience using conjunction or alternative identification IGT. Method: Retrospective review (Libre) 2019–22 7-day criteria: diagnosed >1 peak BG>10% time >7.8 IGT classified max 1 &/or >10% Indeterminate hyperglycaemia (IH) = 4.5–10% Results: Data 28 patients (17M/11F) obtained, mean age 12.75 date test 24 underwent OGTT: Grp A: confirmed (n 2) B: 15) C: Normal OGTT(n 7) recordings demonstrated: 2/2 had by 5/15 diagnosis CGM, whilst 7 IGT, IH was normal 3/7 (4 did not have after OGTT) In addition, n 3 and identified though alone Table 1Utility versus 20)CGM CFDCGM: normalOGTT CFD20OGTT- normal513Sensitivity 2/7 (29%), Specificity= 13/13 (100%) Open table a new tab Sensitivity Conclusion: 1. Recognition GT + more precise CGM. 2. Diagnosing specific poorly sensitive. change approach children CF. We move away annual facilitate granular understanding control, well facilitating earlier CFD.